The Inhibitory Effect of Clindamycin on Lactobacillus in vitro
نویسندگان
چکیده
OBJECTIVE To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobocillus spp. METHODS Concentrations of clindamycin ranging from 1.95-20,000 microg/ml were studied for their effect on the growth of six strains of Lactobacillus. RESULTS Clindamycin concentrations between 1.95-31.25 microg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 microg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1,000 microg/ml. CONCLUSION High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.
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عنوان ژورنال:
- Infectious Diseases in Obstetrics and Gynecology
دوره 9 شماره
صفحات -
تاریخ انتشار 2001